Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. In contrast with other xanthine derivatives, doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. Decreased affinity for adenosine receptors may account for the better safety profile of doxofylline compared to theophylline . Unlike theophylline, doxofylline does not affect calcium influx and does not antagonize the actions of calcium channel blockers which could explain reduced cardiac adverse reactions associated with the drug . The anti-asthmatic effects of doxophylline are mediated by other mechanisms, primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.
Indications: Doseporeterine is mainly used to alleviate symptoms of breathing difficulties caused by bronchial asthma, chronic asthmatic bronchitis, and other bronchospasm conditions. It is typically used as a maintenance treatment.
Contraindications: Those who are allergic to diltiazem or xanthine derivatives, patients with acute myocardial infarction, and lactating women should avoid using this product.
The contraindications of doxofylline mainly include: Those who are allergic to doxofylline or xanthine derivatives, patients with acute myocardial infarction, and lactating women should avoid using this drug. In addition, pregnant women should use it with caution, and elderly patients, due to possible decline in liver and kidney functions, should also use it with caution or adjust the dosage under the guidance of a doctor.
