Orlistat Capsules are long-acting and potent specific gastrointestinal lipase inhibitors and can be used for the treatment of obese or overweight patients (body mass index ≥24).
It exerts therapeutic effects by forming covalent bonds with the active serine sites of gastric lipase in the stomach and pancreatic lipase in the small intestinal lumen, inactivating the enzymes.
Inactivated enzymes cannot hydrolyze fats (mainly triglycerides) in food into absorbable free fatty acids and monoacylglycerols. Undigested triglycerides cannot be absorbed by the body, thereby reducing calorie intake and controlling weight.
Adverse reaction
The common adverse reactions are oily spots, increased flatulence in the gastrointestinal tract, urgency of defecation, increased frequency of defecation and fecal incontinence. With the increase of fat content in the diet, the incidence rate also increases accordingly. Most patients can improve after taking the medicine for a period of time.
